دراسة مناعية في مرضى الذئبة الحمراء الجهازية الذين يشكون من الفشل الكلوي المزمن

Immunological Study in Systemic Lupus Erythoromatosus Patients Complaining from Chronic Renal Failure

   Systemic lupus erythmatosus (SLE) is a chronic systemic autoimmune disease, marked serologically by both humoral and cellular immunologic abnormalities including multiple autoantibodies directed against non-organ specific selected intracellular antigens.
This study aimed to investigate some immunological markers which included (anti-nuclear antibodies, anti-double strand DNA) by used enzyme linked immune-sorbent assay (ELISA) technique, complement factor (C3, C4) by used nephelometry assay related to patients suffering from SLE. And their association with thymosin β4 level and vitamin D3 concentration, in addition to the study of biochemical tests which included cystatin C, urea, uric acid and creatinine.
This study included sixty patients with systemic lupus erythematosus were attended to the Imam Hussein Medical City and thirty healthy control in Kerbala governorate during period from January 2015 to June 2015.
The majority of the SLE patients were female (95%) , the ratio of female male was 19:1. The mean age of SLE patients was (36.11 ±1.53) year ranging from (7-65) compared with healthy control group, who matched in gender and age with patients.
Result’s showed increased concentration of ANA and ds-DNA in patients with lupus nephritis in compared with mild and progressive form of SLE while serum complement factor (C3,C4) showed a significant decreased concentration in patients with lupus nephritis in compared with mild and progressive.
Furthermore, the result showed a significant decreasing in the level of thymosin β4 in lupus nephritis in compared with mild and progressive form of SLE.
The results also demonstrate that there was a significant decrease in vitamin D concentration in patients with lupus nephritis in compared with mild and progressive. On other hand this study showed that the treatment with vitamin D3 supplement play important role as immunomodulate in patients with Systemic lupus erythmatosus.
Finally the results of the study also demonstrate that lupus nephritis in SLE patients has a high significant increasing in Cys-C concentration compared with mild and progressive.
The result can be calculate by using Cys-C index which included arrangement the SLE patients depended on the concentration of Cys-C.
Also, the result showed that Cys-C concentration was a highly significant in Cys-C index as compared with SLEDAI in SLE patients, and founded a more related result between Cys-C concentration, urea and creatinine concentrations in lupus nephritis.