ارتباط مستوى مصل من برديكنين و هجوم غشاء معقد مع التصوير المقطعي المحوسب للرئة في المرضى Covid-19

Correlation of serum Bradykinin and Membrane Attack Complex with severity of covid- 19 regarding Computed Tomography finding

Abstract

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It causes serious respiratory illness such as pneumonia and lung failure. The study aimed to evaluate correlation of Bradykinin, membrane attack complex serum levels, to pulmonary computed tomography scoring in patients with coronaviruses (covid-19).
The study is a cross – sectional that included 90 patients. The participants comprising of 44% severe, 29% moderate and 17% mild patients with covid–19 (56 males and 34 females) who were attending in Al-Hussein medical city, Al-Hayat units, in Karbala, Iraq, were carried out for the period from October 2020 to January 2021. Subjects enrolled in the study were categorized into three group’s patient severe, moderate and mild according to lung involvement diagnosed by pulmonary computed tomography scores under the supervision radiologist. Laboratory tests for serum ferritin, D. dimer, C – reactive protein and hematological parameter were. Sandwich ELISA for patients, were tested for specific serum human Bradykinin and membrane attack complex.
The result of the study revealed that the general mean age in studied groups (48.86±15.73) range (19 – 88) years, a total of 90 patients included 56 males at percentage of 62.2 % and 34 females at percentage of 37.8 %. (40 male, 5 females) are smoker and (16 males, 29 females) are non- smokers. According to the mean serum levels of bradykinin among patient groups were (3.58±1.5 ng/ml) in mild, moderate (8.77 ± 1.74 ng /ml) and severe (20.01±5.72ng /ml), with highly significant (P=0.0005) correlation with covid – 19. Serum level of membrane attack complex showed highly significant (P=0.0001) correlation. The mean serum levels of MAC were (218.75±130.37 ng /ml) in mild, moderate (734.45±466.07 ng /ml), and severe (1130.14±648.78 ng/ml) in covid – 19 patient, the highly concentration of serum levels of bradykinin and membrane attack complex was noticed in severe group when compared with moderate and mild groups according to total lung involvement.

Moreover the mean of total lung involvement in mild (4.94 ± 2.436), moderate (12.59 ± 1.680) and severe was (19.98 ± 2.063), and that showed a highly significant correlation (P=0.0005) with covid – 19 patient groups; a highly total lung involvement in severe more than moderate and mild groups. Total lung involvement and serum levels of BK was significantly different between patient groups (P=0.002, P=0.0005, P=0.0005 respectively), there was a significant positive correlation of MAC with total lung involvement in mild group (P<0.05). On the other hand there was non-significant correlation of total lung involvement with MAC in moderate and severe groups (P>0.05).
Also there was non-significant correlation among total lung involvement, bradykinin and membrane attack complex with hematological parameters (P>0.05). On the other hand a positive significant correlation of total lung involvement with D. dimer and S. ferritin in the mild group (P<0.05) and positive significant correlation of MAC with D. dimer in mild group (P<0.05).There was positive significant correlation of MAC with S. ferritin in severe and mild groups (P<0.05). Significant positive correlation was observed between BK with D. dimer in severe group (P<0.05).