استقصاء ببتيد الدماغ المدر للصوديوم والقدرة الاجمالية لمضادات الاكسدة و الكرياتين كاينيز MB لدى الذكور المصابين بأمراض القلب الاقفارية

Investigation of Brain Natriuretic Peptide, Total Antioxidant Capacity and Creatine Kinase-MB in Males with Ischemic Heart Diseases

Background
Ischemic heart disease is considered one of the most common diseases in the world, which classified to Acute coronary syndrome (ACS) (Unstable angina, Myocardial Infraction), coronary artery disease (CAD) (Chronic Coronary Syndrome), affecting males at a greater rate than females. Some special enzymes related to their work in the heart play a role and are more evident when the heart is stressed, including Brain natriuretic peptide (BNP) which is one of several proteins that help regulate blood circulation throughout the body. Although this protein is made by the heart, providers sometimes call it the “brain” natriuretic peptide because it was first detected in brain tissue.
Total anti-oxidant capacity (TAC) which Antioxidants protect against free radical damage by providing electrons to neutralize them. have a very effective effect in the event of its deficiency, as it is a protective factor against the oxidants to which the body is exposed daily for several reasons, including what is the product of electronic leakage, the electron transport chain, including exposure to radiation, smoking, and indigestible molecules.
Justification:
In an attempt to find a new diagnostic methods and early diagnostic markers that helps clinicians for diagnosis heart attack and angina patients. Such methods should be characterized by accuracy and speed, in addition to being financially inexpensive and easy to apply in the laboratory.
Aim of the study:
The study aims to investigate the association between plasma B-Type Natriuretic Peptide (BNP) concentrations and long-term cardiovascular health, exploring whether this relationship persists or diminishes over time after BNP measurement. Additionally, it examines lipid profile levels in patients with ischemic heart disease compared to a healthy control group, and analyzes the correlation between BNP levels, total antioxidant capacity (TAC), and their impact on long-term outcomes in ischemic heart disease.
Patients and Methods:
This study, which is a case-control study, was conducted on 120 participant with age ranged between (41-70 years), 60 of whom suffered from ischemic heart disease (patient group) and 60 were apparently healthy (control group),who attended the cardiac care unit at the Kerbala Heart Center for the period from December 2022 until July 2023 and who were diagnosed clinically and laboratory according to the standards used for diagnosing acute coronary syndrome and chronic coronary syndrome, and all information was recorded, according to questionnaire paper.
Results:
The results showed that the mean level of BNP (pg/ml) was increased significantly as compared with control group in ACS and chronic CAD with mean ± SD level of 71.42 ±15.56, 55.45±18.21 ACS group and chronic CAD and mean ± SD level of 30.85 ±18.21control group respectively whereas TAC was decreased significantly as compared control group with mean ± SD level of 3.12±0.46, 3.21 ±0.34 in ACS group and chronic CAD and mean ± SD level of 3.47±0.68 in control group respectively.
Conclusion: The study showed that elevated BNP level was an early sign of ACS with higher sensitivity and specificity, while TAC was a protective factor, but with lower sensitivity and specificity. The study showed that CK-MB enzyme activity as a relative indicator (CK-MB RI) of STEMI myocardial infarction was the highest among patients and was followed by NSTEMI then unstable angina (UA) and the lowest was stable angina (SA).