التأيثر الوقائي لل L_Cartine ضد سمية الكبد المستحدثه بالسترابين Cytrabine في ذكور الجرذان

Hepatoprodective effect of L-carnitine against cytarabine induced hepatotoxic in male rats

The study was undertaken to examine the effects of two doses of L-carnitine on liver damage induced by cytarabine including cytotoxic chemotherapy regimens. The study conducted at University of Kerbala / College of Veterinary Medicine. Twenty-four(24) adult male rats were used in the experiment. The rats divided randomly in to four groups each group with six rats, the first group were injected normal saline intraperitoneally and set as control group (G1). The second group were injected cytarabine (25 mg/kg/bw) intraperitoneally and set as (G2).The third group were injected cytarabine (25 mg/kg/bw) and (50 mg/kg/bw) L-carnitine intraperitoneally and set as (G3). The fourth group were injected cytarabine (25 mg/kg/bw) and (300 mg/kg/bw) L-carnitine intraperitoneally and set as (G4) ; The study showed that using of L-carnitine reduced the harmful effect of cytarabine in the body when compared to the group that was injected only with cytarabine at level of (p-value <0.05). The rats that were treated with L-carnitine have shown a significant differences in cytarabine treated group if compared with other groups. The cytarabine group (G2) showed significant increase in serum liver enzymes activities alanine aminotransferase (ALT); gama glutamayl transferase (GGT), angiotensin converting enzyme (ACE), aspartate amino transferase (AST),decrease in antioxidant Super oxide dismutase (SOD) and catalase (CAT) also, increase of the level of malondialdehyde (MDA) when compared to other groups .on the other hand, Experience also showed that there is a signefecant (p-value <0.05) decrease in the level of alanine aminotransferase (ALT),gama glutamayl transferase (GGT), angiotensin converting enzyme (ACE), aspartate amino transferase (AST), malondialdehyde (MDA) and increase in serum in antioxidant superoxide dismutase (SOD) and catalase (CAT) in (G4) group as compeers with (G3) group.
In conclusion The concretion of L-Carnitine 300 mg/kg.BW ameliorating the hyoartoxic effect induced by cytarabine better than 50 mg/kg.BW., Hepatic protection effect of L- Carnitine 300 mg/kg.BW better than 50 mg/kg.BW in hypertoxic effect induced by cytarabine by decrease liver enzyme and The hepatoprtective effect of L- carnitine against cytarabine induce hepatotoxicity manifested by increase antioxidant/oxidant balance and decrease liver damage.