(التقييم البيوكيميائي لاضطرابات عودة الاستقطاب القلبي لدى مرضى عدم انتظام ضربات القلب)

Biochemical Assessment of Certain adipokines and their Association with Cardiac Arrhythmia

background: Among all types of CVDs, arrhythmias are most often responsible for sudden deaths and are indicative of other high-risk diseases. Arrhythmia is the collective term for a variety of conditions that involve a heart rhythm other than sinus rhythm. Adipokines are produced from adipose tissues, which are considered endocrine organs involved in cardiovascular function causing electrophysiological effects such as ionic profiles, contractility in the atrium, and change in morphology of action potential. Nesfatin-1 and chemerin are a newly discovered adipokine, related to the inflammatory process.
The present study aims to examine the diagnostic ability of adipocytokines (Nesfatin-1 and chemerin) and their ratio in SVT arrhythmia cases.

Material and methods: The study recruited 60 patients and 30 healthy controls. These patients were divided into two subgroups of SVT, certain etiology of SVT cases with clear history of one or more of the risk factors such as (lipid disorder, thyroid disorder, DM, hypertension), and uncertain etiology of SVT cases without any previous history. Serum Nesfatin-1 and chemerin were measured using the ELISA technique. Some related parameters were also determined and correlated with the level of these adipokines.
Results: The mean level of serum nesfatin-1 was significantly higher in normal subjects than in both SVT with risk factor & SVT without risk factor etiology groups.
Estimation plot of determination serum level of Chemerin indicted a massive increased level in SVT without risk factor patients compared the other groups.
Binary logistic regression was performed. It was found that chemerin in SVT with risk factor and SVT without risk factor etiology SVT patient (OR: 1.008 and 1.018; 95% CI: (0.998 – 1.018), (1.008 – 1.028) respectively, were independent risk factors. while Nesfitin (OR: 0.960 and 0.946, 95% CI: (0.929 – 0.992), (0.913 – 0.980) were independent protective factors for arrhythmia SVT patient. Results of the receiver operating curve (ROC) and AUC analysis for the optimal diagnostic points for predicting SVT without risk factor etiology of SVT cases was indicated that chemerin was demonstrated the most interesting prediction (sensitivity = 0.60.%, specificity = 0.89%) at a level = 733.55).

Conclusions: Nesfatin-1 and chemerin levels are affected by SVT arrhythmia disease when adjusted for other cofounders. The present results suggest that serum chemerin can be used as an inflammatory marker of SVT arrhythmia patients as it has good sensitivity and specificity.