العلاقة بين Lipopolysaccharide binding protein, Mannose receptor, IL-1β and IL8 في مرضى التهاب المجاري البولية

Correlation of Lipopolysaccharide Binding Protein, Mannose Receptor, IL-1β and IL8 among UTI Patients

Abstract

One of the most common types of infections in the world is urinary tract infections, or UTIs. UTIs are associated with a significant clinical and financial burden as well as a reduced quality of life for patients. Both sexes can get a UTI at different ages, and women are usually more susceptible than men. The rationale stems from differences in the structure and physiology of the urinary system between the sexes.
This study was conducted during the period from October 2023 to February 2024 at Imam Hussein Hospital in the holy city of Karbala and the laboratories of the College of Applied Medical Sciences/University of Kerbala.
A case-control study design was conducted. The current study including collection urine samples (for use in general urine examination and bacteriological culture) and blood using blood directly to measure the complete blood count CBC and serum to measure C- reactive protein (CRP), interleukin one beta (IL-1β), interleukin eight (IL-8), and lipopolysaccharide binding protein (LBP), mannose receptor (MR) from 70 patients with UTI (35 patients with positive bacterial growth and 35 patients with negative bacterial growth) in addition to 70 control people. The following general criteria were also investigated: age, sex, BMI.
The age of the study subject ranged from 18 to 77 years, and the percentage of females for each group is significantly (P<0.05) greater than the percentage of males for each group (the percentage of females was 80% and males 20%). The majority of age groups with urinary tract infections were from 18 to 38 years. Gram-positive bacteria appeared at a rate of 52% and gram-negative bacteria at a rate of 48%. Eight bacterial species were obtained, distributed as follows: Escherichia coli (33%),

Staphylococcus saprophyticus (26%), Staphylococcus haemolyticus, Staphylococcus aureus, and Klebsiella aurogenes (10%), Klebsiella pneumoniae (5%) also Enterococcus faecalis and Enterococcus faecium (3%).
The most important concluded of the study is the increase in the following parameters: CRP, IL-1β, LBP, MR, and pus cells in patients with urinary tract infections compared to the control group. It was also found that the increase in the concentration of the LBP and MR in the group of patients who had positive bacterial growth was significant compared to the control group and the group of patients who had negative bacterial growth.
The current study also concluded that there is a significant direct correlation in the group of patients who had bacterial overgrowth between: (WBC and CRP) and (Neutrophils and IL-8). In addition to the presence of a negative correlation between (WBC and MR) and (LBP and IL-1β). Correlations between markers in the group of patients without bacterial growth indicate that there is a positive correlation only between (LBP and IL-8).