تأثير المستخلص الكحولي لإزهار نبات القرنفل (Eugenia caryophyllus) على كبد وكلية ذكور الجرذ الأبيض المعاملة بعقار السايكلوفوسفامايد دراسة وظيفية ونسجية

Effect of alcoholic extract of carnation plant flowers (Eugenia caryophyllus ) on liver and kidney of white male rate with cyclophosphamide Histo- physiological study

This study was proceeded in order to Know some of the physiological, chemobiological- effects of weight effects in addition to the appearance and pathological tissue resulted from the alcoholic extract on white male rats dealt with cyclophosphamide drug as two experiments were done , first one included injection for several rats by cyclophosphamide drug of 20 mg/kg concentration for 30 days and then withdrawing the blood from these rats that were injected with above mention drug to see the pathological effects occurred to the fore – come up with incorporeal increase by (P<0.05) in (LH), while there is incorporeal decrease(P<0.05)  for each hormones of (Testosterone,GH,T3,T4), while the chemo- biological standards shows a incorporeal  increase  (P<0.05) in enzymes of liver and urea, total bilirubin, total  cholesterol  and the enzyme Lactate dehydrogenase ). Also there were some aspect changes like lack of desire to eat, brown urinary and yellow skin, textural change for both of liver and kidney that included a sudden change in cytoplasm of liver cells, inflation of kuppfers cells, inflame in the central vein of liver, also happen the phenomena of glomerulus inflammation and alienation for the covering cells of kidney pipes, bleed and enlarging of Henley Loops .

    In the second experiment, three concentrations of alcoholic carnation are (300) mg/kg, (400) mg/kg, (500) mg/kg and each group of has been fed with one of these concentrations for 30 days, blood has been withdrawn , bodies of rat were slashed to know the effects of the extract on the weight, physiological and chemo- biological, in addition to the aspect effects and pathological textural effects on liver and kidney , it turns up that carnation extract for all used concentrations results in incorporeal decrease  (P<0.05) in the level of hormone (LH) , while there is a incorporeal increase (P<0.05) happen in for all hormones of (Testosterone, GH,T3,T4), while the chemo-biological standard shows incorporeal decrease (P<0.05) in the levels of enzymes of liver and urea. Total bilirubin,total cholesterol and Lactate dehydrognease .

    The  effect of  the extract on textures of kidney and liver that extract on concentration of 500 mg/kg in decrease the intoxication effects of cyclophosphamide on the tissue of kidney and liver , while the both other concentration of (300.400) mg/kg has not such effects .