تأثير L-camitin علئ بعض المؤشرات الحيوية في المرضى الذين يعانون من مرض الكلى المزمن

Effects of L-camitin on some biomarkers in patients with chronic kidney disease

This study was conducted to investigate the effect of L-Carnitine on chronic renal failure patients undergoing dialysis. The study included 40 patients, aged between (21-62) years. The study was divided into two phases, the first phase (pre-use of treatment) and the second phase (post-use). L-Carnitine Extra treatment was given to dialysis patients at a dose of (1600) mg per day orally for a period of three months. Samples were taken from Imam Al-Sadiq Teaching Hospital in Babli Governorate, Division of the Industrial College (dialysis) during the time period from 14/8/2022 (August) to 4/3/2023 (March), where parathyroid hormone (PTH) was measured by ECLIA technique and using COPA immunoassay analyzer device from Roche company in Switzerland, calcium and phosphorus were measured by spectrophotometer, albumin was measured by Human Star 300SR device in France, hemoglobin was measured by CBC Cell Tac device in Japan, and CK enzyme was measured by Fujifilm device in Japan.
In the results of the statistical analysis, the study concluded that there is a significant difference in parathyroid hormone, calcium, phosphorus, albumin, hemoglobin, and creatine kinase enzyme in dialysis patients after using the treatment compared to the pre-treatment stage, where we noticed a decrease in the level of PTH, PO4, and CK enzyme after treatment, and an increase in their Ca, albumin, and hemoglobin levels compared to what they were before treatment.
The results of the study also showed that the treatment had a clear effect on the level of vital parameters for dialysis patients with a shorter period of time (the duration of the disease is less than three to six months), as well as patients who had fewer dialysis sessions per week than (1-2) times per week.
During this study, patients who were treated with L-Carnitine commented that they felt an improvement in their health and noticed an improvement in their ability to walk long distances and an increase in physical endurance, in addition to their ability to reduce the number of hours of dialysis session, which they were not able to do before using the treatment.