تحضير بوليمرات مشتركة جديدة من الماليئميدات كنظام ناقل للدواء ودراسة فعاليتها ضد السرطان

Synthesis of New Co-Polymers Based Maleimide As Drug delivery System and Study their Anti Cancer Activity

In this work, five new drug substituted monomers and their new homogenous and heterogeneous polymers were synthesized which loaded with medical properties to extended the controlled drug.
This work included following lines:
First line:
The first step includes preparing Maleimic acid (F1) via reaction of maleic anhydride with 4-aminobenzoic acid, then compound (F1) was converted to its corresponding acylchloride derivative(mF1) which reacted with different amino drugs such as (Theophylline, Chlorodizepoxide, Pseudoephedrine, Paracetamol , Sulfadizine ) afforded (F2-F6) monomers.
Second line:
The homogeneous polymers (F7-F11) were synthesized through the polymerase reaction of the free radicals of the monomers (F2-F6) under the nitrogen using (MEKP) as initiator.
Third line:
The heterogeneous polymers (F12-F16) were introduced through the polymerase reaction of the free radicals of the monomers (F2-F6) separately with the acrylic acid under nitrogen using (MEKP) as initiator.
Forth line:
All of these monomers and polymers are characterized by FT-IR, 1 H-NMR and 13C-NMR spectroscopies. Drug release under control and swelling were studied at different pH values at 37 °C. The viscosity was measured at 25 °C using the Ostwald viscosity scale and applied the solubility properties of these polymers.
Some of the physical properties of all monomers and polymers were studied.

Fifth line: cytotoxicity and antioxidant analyses The properties of biological activitywas studied.The anti-proliferating effect of drug-loading F7, F9 and F12 against the breast cancer cell lines was evaluated.
Based on cytotoxicity analyses, it can be concluded that F7, F10 and F15 may be an appropriate and promising strategy for developing effective drug delivery system to clinical application against breast cancers.

The results of antioxidant agreed with the findings that indicated F10, F15, and F16 enhanced antioxidant activity of drugs. The enhanced antioxidant activity of modified drugs could be attributed to the enhanced solubility and dissolution rate.The following schemes were illustrated the summarized synthesis lines:-