تحضير وتشخيص معقدات تحتوي على مجموعة البيتا-لاكتام مع بعض العناصر الانتقالية ودراسة فعاليتها ضد البكتيريا المرضيه الحيوية

Preparation, Characterization and study of Complexes Containing Beta-lactam group with Some Transitional Elements and their Biological Activity Against Pathogenic Bacteria

Abstract

In this work, four new ligands have been prepared by the reaction of 6-amino penicillanic acid (6-APA) with Schiff bases to produce azo-azomethine ligands HL1, HL2,HL3 ,and HL4 respectively. Its includes preparation of 6-amino-penicillinic acid derivative from the reaction of Schiff base compound (Z)-3-((3-hydroxybenzylidene) amino) phenol) with 6-amino-penicillinic acid and linking them by the Azo bond To form ligand (HL1),and use The“(Z)-3-((3-hydroxybenzylidene) amino) phenol) Schiff base in the preparation of (HL2 ) ligand ,(HL3) ligand was prepared by reaction the of 3-(((4-hydroxyphenyl) imino) methyl) phenol with 6-amino penicillanic acid (6-APA),and use the 3-((4-(dimethylamino) benzylidene) amino) phenol (Schiff base compound)to formation of (HL4) , also study the physical properties of the ligands (azo-azomethine ligands) and identifies there composition by various techniques such as1HNMR, mass spectroscopy, UV-visible, and FTIR. The result indicates that the prepared ligands acted as a tridentate ,New complexes have been prepared by the reaction of the above derivative ligands with metal ions Cu (II), Ni (II), and Fe (II) that HL1, HL2, HL3, and HL4 have interacted with these metal ions in mole ratio [1:2]. The synthesized complexes are characterized using , CHNs, atomic Absorption, Uv-Visible, and FT-IR, Magnetic Moment, and Molars Conductivity for all prepared compound. The results show that the complexes suggested be with octahedral geometry with d2sp3 and sp3d2. The antibacterial activity of the synthesized compounds is studied against (Staphylococcus aureus) using the minimum inhibitory concentration (MIC). The results show that (MIC) of the prepared compounds has inhibition activity against (Staphylococcus aureus) bacteria and obviously affects the ability of pathogenic bacteria (S. aureus) to attain virulence factors such as biofilm and hemolysin toxin.