تحضير ودراسة بوليمر مشترك جديد كموصل للدواء

Preparation and Study of New Co-polymer As A Drug Delivery

  In this work, a new co- polymers was synthesized from the reaction of pentarythritol with fumaric acid to form the linear co- polymer at 240 Co, as in the following scheme. The product co-polymer was identified by FT-IR and 1HNMR spectroscopy. Three different moles of acrylic acid monomer (0.5, 1.0 and 1.5 mole), were added to obtain three new co- polymers

   The swelling ratio was measured for all the hydrogel samples, in three different media (pH=2.2), (pH=7.0) and (pH=8.0) at constant temperature 310K, as function of time. Albumin was loaded into polymeric matrix by immersing the hydrogel in buffer solution (pH=2.2) and (pH=8.0) was allowed to load at temperature 310K, the concentration of albumin released was measured on UV-Vis spectrophotometer. The drug release studies from the albumin loaded hydrogel was studied in two different media (pH=2.2), (pH=8.0), at temperature 310K as function of time. Where observed when increased drug concentration leads to increase in the release process.
The results obtained showed that the protein loading and release process in the basic medium were higher than in the acidic medium, indicating that the combined co-polymer is selective in the medium.