تخليق مركبات عضوية نانوية خضراء بطرق تحليلية ودراسة فعاليتها البيولوجية

Synthesis of Green Nano – Organic Compounds By Using Analytical Method and Study Their Biological Activity

The aim of the work reported in this thesis is to develop methods suitable for the green analytical synthetic method of valuable materials of Nano-organics cleanly and efficiently. The use of organic nanoparticles derived from biomass in the medical and pharmacological studies has increased in terms of published research studies. The main aim of this study was to validate the use of edible fresh potato for the synthesis of Nano cellulose. In this procedure, there are no chemicals were used in any step. This method was performed to prepare nanoparticles extracted from potato through natural extraction and physical technical steps.
It was found that the FTIR spectra confirmed the presence of amorphous (Nano crystalline) cellulose’s structure by detecting several functional groups such as (-OH) broad (3100-3600 cm-1), (C-H) (2800-3000 cm-1), (C- H) symmetric bending (1400 cm-1), and (C–O–C) stretching (856 cm-1).
AFM measurements and SPM analysis reports were proved the Nano scale of prepared cellulose particles by showing the average diameter was (23.44 nm) and median diameter was (18 nm) of Nano cellulose according to granularity cumulation distribution chart, while the average height was (12.714 nm) according to the height cumulation distribution chart. Surface topology and roughness analysis and parameters were discussed.
At applicable scale, different equivalent ratios of Nano cellulose were used with the medicines to find out the best quantity of nanoparticles that can be used for the purpose of encapsulating the medicine and keeping it from liberating and losing quantities of it in the acidity of the stomach, and then transferring it to the safest area of greatest absorption in the human body (small intestine, alkaline medium).

The retention ability reaches up to (70 %) for aspirin; the retention ability reaches up to (54 %) for paracetamol; the retention ability reaches up to (44
%) for Flagyl by using 4 equivalents of Nano cellulose.
The order of medicine response to the controlled Nano carrier system (Nano cellulose) statistically was in the following order:
Aspirin < Paracetamol <Flagyl