تخليق وتشخيص مكونة نانوية من الفضة واوكسيد الزنك ودراسة تطبيقاتها الدوائية

Synthesis and Characterization a Nano Composite from Silver and Zinc Oxide and Study its Pharmaceutical Applications

Abstract

The current study included the preparation of two hybrid nanocomposites of silver and zinc oxide, the first laboratory prepared silver and the second commercial nucleus silver, which were inserted between zinc oxide layers and they were diagnosed and some of their bioactivity studied. The results showed the following: 1- The two nanocomposites were prepared from silver and zinc oxide using the ion exchange method between silver and zinc oxide. 2- The aforementioned hybrid nanocomposites were diagnosed by spectroscopic methods, as X-ray diffraction spectroscopy (XRD) revealed the emergence of new diffraction levels for the two hybrid nanocomposites compared to the diffraction spectrum of dihydroxide and zinc oxide. The infrared spectroscopy (FT-IR) revealed the emergence of new groups in the spectrum of the two hybrid nanocomposites compared with the spectrum of dilayer hydroxide and zinc oxide, which indicates obtaining two new compounds. 3- The scanning electron microscope (SEM) image showed changes in the surface of the two hybrid nanocomposites compared with the hydroxide and zinc oxide di-layers. The two-dimensional and three-dimensional atomic force microscopy (AFM) image of the two nanocomposites under study also proved that the compounds were obtained within the nanoscale and dimensions which are consistent with the results of X-ray diffraction (XRD). 4- The process of releasing the medicinal substance Rifampicin from between the layers of the two hybrid nanocomposites referred to above was studied into three media, as it was observed that the process of Rifampicin liberation occurs rapidly at the beginning of the release and then gradually slows down with the passage of time. The results also showed an increase in the percentage of liberation by increasing the concentration of the medium, as well as an increase in that percentage in the acidic medium compared to the basic medium. 5- The results were the inhibitory activity of the two hybrid nanocomposites A- The antioxidant efficacy of the free radical scavenging method (using the root DPPH) possessing the two hybrid nanocomposites at the same concentration reached 75 micrograms / ml, while that value was 25 micrograms / ml for the OG compound.