تقيم التأثيرات الوقائية لسبايرولينا ضد الفشل الكلوي المزمن الذي تم استحداثه بواسطه بالادنيين في ذكور الجرذان

Evaluation of the Protective Effects of Arthrosporia Platensis (spirulina) Against Induced Chronic Renal Failure by Adenine in Male Rats Rattus norvegicus

The present study aims to evoluate the role of spirulina in reduction the ability of adenine induces renal failure and its complication in male rats. The study conducted at College of Veterinary Medicine /University of Kerbala during period from December 2019 to April 2020 . Thirty two adult male rats used in the present study and divided into four groups , first group consider as control group , the second group received adenine ( 100 mg / kg BW) intraperitoneal , while the third group receive adenine ( 100 mg / kg/BW ) intraperitoneal combined with spirulina suspension (750 mg /kg/BW) and the fourth group received just spirulina suspension (750 mg /kg/BW) orally also with feed , at the end experiment blood was collected to assessment kidneys function (KIM-1,urea and creatinine), and the liver function parameters (AST and ALT),lipid profile( cholesterol ,triglyceride ,LDLand HDL).Antioxidant parameters (SOD,GSH,MAD and NO) and hematological parameter (Red blood cells, hemoglobin, PCV, platelets and WBC). kidney and liver isolated to study of histological changes. Results showed significance (p≤0.05) increases in kidney function test and results showed significance increase (p≤0.05) of lipid profile parameters in (cholesterol, triglyceride and low density lipoprotein) in the second group which administrated adenine while high density lipoprotein was decreased in the same group in the comparison with other groups. the results showed significance (p≤0.05) decrease in the GSH, SOD and increase in the MAD and NO in the second group in comparison with other groups. Results showed significance (p≤0.05) decrease in RBC, Hb, PCV and platelets in the second group in comparison with other groups while WBC was increased in the second group in compared to other groups. The results in the third group which received the spirulina suspension co_adminstrated
with adenine as antioxidant showed significance enhancement in the most of parameters which studied to return nearlly to the control group levels