تقييم تأثير الصبار ضد ارتفاع السكر في الدم وفرط دهون الدم في ذكور الجرذان المعرضة للديكساميثازون

Evaluation Effect of Aloe Vera Against Hyperglycemia and Hyperlipidemia in Male Rats Exposed to Dexamethasone

Abstract
Chronic administration of dexamethasone (DXM) causes hyperglycemia and hyperlipidemia, so the present study was undertaken to observe the effect of the aqueous leaf extract of Aloe Vera gel in the reduction in blood glucose, lipid level in hyperglycemia and hyperlipidemia in male rats. The study was conducted at University of Kerbala / College of Veterinary Medicine during period from November 2021 to April 2022.
Twenty four adult male rats used in the present study and divided into four groups, first group (G1) is considered as control group received normal saline, the second group (G2) received dexamethasone (1mg/kg/bw) intraperitoneally, while the third group (G3) received dexamethasone (1mg/kg/bw) intraperitoneally combined with Aloe Vera leaf gel extract (300 mg/kg/bw) in aqueous solution daily using an intragastric tube. The fourth group (G4) received dexamethasone (1mg/kg/bw) intraperitoneally combined with Aloe vera leaf gel extract (500 mg/kg/bw) in aqueous solution daily using an intragastric tube, at the end experiment blood was collected to assessment glucose, and, lipid profile (cholesterol, triglyceride, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), and high-density lipoprotein (HDL). Levels of malondialdehyde (MDA), heat shock protein 70 (HSP70), and angiotensin converting enzyme (ACE). Pancreas and liver isolated to study of histological changes. The current results showed a significant decrease (p˂0.05) in serum glucose at the (G3) and (G4) groups respectively compared with the (G2) group. A significant decreased (P˂0.05) were noticed in the serum concentration of cholesterol, triglyceride, VLDL and LDL at the (G3) and (G4) groups respectively in comparison with the (G2) group. HDL increased significantly (P˂0.05) in the same groups. A significant decreased (P˂0.05) was noticed in the concentration of MDA, HSP70 and ACE in the (G3) and (G4) groups respectively compared with the (G2) group.
Histological changes in liver and pancreas of the rats demonstrate that dexamethasone treated group showed significant structural changes and damage. In addition, Aloe Vera 500 mg/kg/bw working better than Aloe Vera 300 mg/kg/bw leaf gel extract-treated rats were improved the harmful effect of dexamethasone in the histopathological studies in liver and pancreas of the rats when compared to the group that was injected only with dexamethasone
In conclusion of our results, we conclude that Dexamethasone leads to side effects in high sugar and high fat, which leads to harmful effects on the liver and pancreas. While taking Aloe Vera Gel with Dexamethasone improves this studied information.