تقييم مستويات بعض عوامل الالتهابات في مريضات متلازمة تكيس المبايض ومقاومة الأنسولين

Evaluation of Some Inflammatory Factors in Patients of Polycystic Ovary Syndrome with Insulin Resistance

Summary
“Polycystic Ovarian Syndrome (PCOS) is one of the most prevalent metabolic and reproductive illnesses, Menstrual irregularities and androgen excess are two symptoms that PCOS-affected women experience, and these symptoms have a substantial negative influence on their quality of life. They may have a higher chance of developing a number of morbidities, such as obesity, type II diabetes, cardiovascular disease (CVD), infertility, cancer, mental health issues and insulin resistance. Insulin resistance (IR) is a failure in insulin-mediated control of glucose metabolism in tissues.It is the most common form of PCOS, and it causes the ovaries to generate more androgen, which causes oligo-ovulation or anovulatory.”
“This study was designed to evaluate the levels of some inflammatory factors in polycystic ovary syndrome and insulin resistance patients. The study included 80 women between the ages of 16-40 years, divided into 40 patients with polycystic ovaries and insulin resistance, and 40 women as a healthy control group. Each sample measuredthe following parameters LDL, HDL, Triglyceride and Cholesterol using the BS-430 device from Mindray company, while high sensitivity C-reactive protein was measured using BS-200 from Mindray company and human interleukin-6 was measured using MAGLUMI 800 from Snibe company. The results of the statistical analysis found that there was a significant difference in Low Density Lipoprotein(LDL), High Density Lipoprotein(HDL), Triglyceride, Cholesterol, High sensitivity C-reactive protein, Human Interleukin-6 in patients women compared to the control group, As LDL, Triglycerides, Cholesterol, High-sensitivity C-reactive protein, and Human interleukin-6 increased, HDL decreased in the patients group. A positive correlation was found between triglycerides and each of High-sensitivity C-reactive protein, Human interleukin, and insulin resistance. In addition as a negative correlation was found betweenHDL and Human interleukin-6, and a positive correlation between each of High-sensitivity C-reactive protein and Human Interleukin-6, also it showed that female patients over 30 years of age have anincreased levels of LDL, Cholesterol, High-sensitivity C-reactive protein, and Human interleukin-6 compared to female patients under 30 years of age,while there is no significant value in a Triglycerides, HDL and insulin resistance in relation to the patients’ age.The results also showed a significant relationship in the body mass index, exist in the two study groups. Obesity was more prominent in the patients group. The effect of blood pressurecompared between the two groups. The was no significant relationship shown between Interleukin-6, High Sensitivity C-Reactive Protein, Insulin resistance, and disease duration.”