جزيئات الالتصاق لخلايا الباطنية الوعائية كمؤشرات لشدة COVID-19

Vascular endothelial cell adhesion molecules as predictors for severity of COVID-19

Abstract

The Coronavirus disease 2019 (COVID-19) pandemic continues to spread across the world. Hence, there is an urgent need for rapid, simple, and accurate tests to diagnose severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.
Aims: The present study was conducted to investigate the impact of
serum levels of vascular endothelia cell adhesion molecule (VAP-1and VCAM-1) in severity of COVID-19 in studied subject .
Materials and methods: A cross sectional study for Iraqi individuals with COVID19 in Kerbala province. The severity of COVID -19 varies; therefore, we included 69 patients in mild presentations and 19 cases with severe form of this disease. The number will be according to the sample size equation. Five ml of blood sample was collected and processed and
the serum will separated for measuring the biochemical parameters.
Results: The median of VCAM-1 in diabetics was199 (pg/ml) and in non-diabetics 195.75 (pg/ml) (NS), the median VAP-1 in diabetic group was 3690(pg/ml)and in non- diabetics 3678.50(pg/ml) (HS). In another hands, the median of VAP -1 was 3719.50(pg/ml) in hypertensive group compared to 3600.50(pg/ml) in none hypertensive one. In contrast the
VCAM-1 median in none hypertensive patients was higher than with hypertension (199,195.75 (pg/ml) respectively). Also, in smokers groups the median of VCAM-1was more than in non-smoker (236 versus 180.30pg/ml) (S), while the median of VAP-1 in smoker patients was greater than in non-smokers (3698, 3550pg/ml respectively) Finally, the
median of VCM-1 in patients with mild degree of COVID- 19 Disease was 198.30, which was less than in patients with severe disease 271.31(pg/ml) (S), while the results for VAP-1 in mild cases was higher than severe cases (3678(pg/ml), 3664(pg/ml respectively).
Conclusion: According to the results of this study we concluded that a serum level of VAP-1 was associated positively with diabetics, hypertension and smoker states in COVID -19 patients.
In addition, serum level of VCAM-1 was also associated positively with diabetics, hypertension and smoker states in COVID-19 patients.