دراسة الامتزاز للتفاعل بين اوكسيد الزنك النانوي مع الالبومين والكرياتينين

Adsorption Study Of The Interaction Between Zinc Oxide Nanoparticles With Albumin And Creatinine

Abstract
The subject of this thesis is concerned with the adsorption of albumin and creatinine onto the surface of zinc oxide nanoparticles.
Initially the surface was prepared and characterized by using; Fourier infrared spectroscopy (FT-IR), atomic force microscope (AFM), scanning electron microscopy (SEM), and X-ray diffraction Spectroscopy (XRD).
A series of batch adsorption experiments were carried out under various operating conditions; equilibrium time, amount of adsorbent, pH, temperature, initial concentration of albumin and creatinine and shacking speed.
The results showed that the creatinine required a shortest equilibrium time (2.5 min.), while albumin has (30min.) to reach equilibrium time, and found that the adsorption percentage of albumin was higher than creatinine by 28% .
Following optimization of variables, the relation between concentration of albumin and creatinine remained in aqueous and onto ZnO nanoparticles has been evaluated using various adsorption isotherm models, such as Langmuir, Freundich and Temkin.
The values of correlation coefficient (R2) showed that the Langmuir and Temkin equations appear to fit the equilibrium data better of adsorption of albumin and creatinine than Freundlich equation.
Thermodynamic parameters such as enthalpy (∆H), entropy (∆S) and Gibb’s free energy (∆G) were also calculated. It was found that the adsorption process of albumin and creatinine onto ZnO nanoparticles were feasible, spontaneous, endothermic, increasing randomness in a system and physisorption.