دراسة بعض المؤشرات الكيموحيوية والدمية للاشخاص غير المصابين والملقحين بلقاحات فايروس كورونا.

Study of some Biochemical and Hematological Indicators in non-Infected People and Vaccinated With Corona Virus Vaccines .

Abstract
The study aimed to determine the effects of the approved vaccines for COVID-19 in Iraq (Pfizer, AstraZeneca, and Sinopharm) on liver and kidney functions and blood pictures of people, who were not previously infected with the virus, ranging from vaccinated and non vaccinated, and of both sexes. Their total number was 280 people. 70 samples of Pfizer vaccine, 70 Sinopharm, and 70 AstraZeneca, as well as 70 samples for the control group, for ages between (18-70) years, in the period from October 2021 to the end of April 2022.
The results of the study showed the ratio of females to males (46% ♀ / 54% ♂), and that the highest percentage in the age groups, which was 21-30 years old, consisted of 40.0% in the control group. Those vaccinated with the Pfizer vaccine followed with the age group (21-30). And with Sinopharma, it was (41-50) which was (30.0%). While those vaccinated with the AstraZeneca vaccine have the lowest percentage of them (27.1%), in the age group (21-30). The results of the study also recorded that there was no significant difference in the biochemical parameters of blood and liver and kidney functions when comparing the vaccinated with the unvaccinated at the level of probability (P < 0.05).
The results of the study showed the effect of the type of vaccine on liver function, as the highest value of Aspartate transaminase (AST and alanine transaminase (ALT) readings) was recorded for those vaccinated with the Pfizer vaccine, the lowest value for those vaccinated with Sinofarm, and the highest value for Total Serum Bilirubin (TSB) B and (ALP)(Alkaline phosphatase) for those vaccinated with the AstraZeneca vaccine. The results of the current study also showed the effect of the type of vaccine on kidney function, as it recorded the highest value of (Blood urea Calcium (Ca++) BU) for those vaccinated with the Pfizer vaccine, and the highest value of creatinine (Cr) in all the vaccines used (Pfizer, AstraZeneca and Sinopharm). The highest value of Uric acid (UA) was detected in the AstraZeneca vaccine, and the highest value of (RBS) Blood sugar random in Sinopharma vaccine.
The results of the study showed the effects of the type of vaccine on the blood picture, as it recorded the highest value of (White blood cells (WBC) and Packed cell volume (PCV)) for those vaccinated with AstraZeneca, and the highest value of Red blood cells (RBC) and Hemoglobin (Hb)) for those vaccinated with the Pfizer vaccine, and the highest percentage of (PLT) platelets for those vaccinated with the Sinopharma vaccine. The results of the study also indicated the effect of sex on liver function, as the highest concentration of AST enzyme (ALT) was recorded for males vaccinated with Pfizer vaccine, and the highest concentration of ALP in males vaccinated with Sinopharma, while the highest concentration of TSB was for females vaccinated with AstraZeneca.
The results of the study of the effect of sex on kidney function indicated that the highest concentration of BU was in females vaccinated with Pfizer vaccine, and the highest concentration of (Cr and UA) was in males vaccinated with AstraZeneca vaccine, while the highest concentration of RBS was in females vaccinated with Sinopharma, and the highest concentration of Ca++ in Males vaccinated with the Pfizer vaccine. As for the effect of sex on blood picture indicators, the highest concentration of WBC was in the males vaccinated with AstraZeneca vaccine, the highest concentration of RBC in the females vaccinated with the Pfizer vaccine, the highest percentage of Hb in the males vaccinated with the Pfizer vaccine, the highest concentration of HCT in the males vaccinated with Sinopharma, and the highest concentration of PLT in females vaccinated with the Sinopharm vaccine. The results of the study showed the effect of weight on liver function, as the highest concentration of AST enzyme (ALT) and (ALT) was observed for people with weights (75kg-95kg) and those vaccinated with Pfizer vaccine.
And also, the highest concentration of ALP happened to be in people with weights (>95kg) and vaccinated with Sinopharma vaccine, and the highest concentration of TSB for those vaccinated, with weights (<75) and those vaccinated with the AstraZeneca vaccine. As for the effect of weight on kidney function, the highest concentration of BU for people (>95kg) was recorded in the Pfizer vaccine, and the highest concentration of (Cr and (UA) was in people with weights (<75kg) in AstraZeneca vaccine. The highest concentration of RBS was in people with weights (75- 95)kg and vaccinated with Sinopharma, and the highest concentration of Ca++ happened to be in people with the body weight (<75kg) and vaccinated with Pfizer. The results of the effect of weight on the blood picture showed that the highest concentration of WBC in the subjects (>95kg) and those vaccinated with AstraZeneca vaccine, and the highest concentration of RBC and Hb was found in the subjects (>95kg) and vaccinated with Sinopharma vaccine, and also, the highest percentage of PCV was found in the subjects with weights (<75kg) and vaccinated with AstraZeneca. The highest concentration of PLT was in subjects (>95kg) and also vaccinated with Pfizer.
It is concluded from the current study that the changes in the biochemical and hematological parameters differ according to the type of vaccine, age, gender and weight. It also proved that the vaccines are safe in view of the absence of significant and insignificant differences in the indicators of liver and kidney function and blood picture.