دراسة حركية عقار الرايفامبسين من بين طبقات مغنيسيوم/ المنيوم الثنائية الهيدروكسيد

The study of kinetic of Rifampicin drug from Magnesium/ Aluminum layered double hydroxide

The term ‘Nano’ is used to describe one or more of the components of a material that have at least one dimension ranging from 1-100 nano-meter. The significant composition of the layers double  hydroxide drew the attention of the experts to make use of it. as well as the ion exchange ability between the layers. Therefore, the layers of the double Hydroxide composition attracted many of the Biomedicine specialists. And, throughout the scientific development the solubility of such composition proved the safety must be taken into consideration to maintain the stability of the medicine chemically and physically in addition to its efficiency. Also, this method was used to improve the solubility, to control the medicine release in the human body, and to determine the level of toxicity during the first levels of its development to improve the medicine and  reducing the particles to a nano-size particles.

The Rifampicin  is considered one of the most important medicines in the treatment of Tuberculosis. And considering the fact that it is unstable and contains some demerits like the low rate of solubility in water. Also, having too much or too little of it might does harm to the body. So, in order to limit the shortcomings of this medicine, this study was performed, including the preparation of some Mg ̷ Al- Rifampicin-layered double hydroxide compositions   of different Molar ratios (R= 2,3,4,5) using the direct and indirect methods and at  70 Cᵒ.

The studies of the X-rays diffractions (XRD) showed the best Molar ratio to prepare the compounds is (R=5) because it shows peak of high intensity which indicates that the crystal is more stable. In addition, the XRD showed that putting the Rifampicin in between the Magnesium/ Aluminium layers was done successfully comparing the thickness rates of the layer before and after putting the Rifampicin. Also, the Hybrid Nano compounds were diagnosed using  (FTIR) Spectroscopy. And, the release mechanisms of the Rifampicin to a variety of aquatic environments such as Phosphate and Sulphate in different concentrations, and other more acidic aquatic environments similar to those of the digestive acid using the different acidic equations along with Bashkar’s, they were all studied and the study showed that the release ratio and mechanism are all controlled by the second pseudo order.

In addition to what preceded, equations regarding the analysis of the particles and ions diffusion among the hybrid Nano compounds groups have been studied, as well as studying the mechanisms of the Rifampicin distribution from among such groups in different aquatic environment such as the Phosphate ions and the those of Sulphate as well in the different concentrations of those compounds, and also in the different aquatic environment of higher levels of acidity.

The developed equations of second diffusion has been applied and proved to be more applicable regarding the ionic transparency from among the molecular groups of the hybrid Nano compounds than the former equations.