دراسة مستويات الانترلوكينات 17 ، 23 والمستلمات الشبيهة بالتول 4 ، 7 في مصل مرضى الصدفية

Study the serum levels of Interleukin 17 & 23 and Toll-Like Receptors 4, 7 in psoriasis patients

Psoriasis is an autoimmune disease that affects the skin and has a complicated hereditary and immunological basis. Psoriasis treatment may be improved with a better understanding of the involvement of immunological markers and socio-demographic factors. The purpose of this study is to examine the relationship between immunological markers (IL-17, IL-23, TLR-4, and TLR-7) and several socio-demographic parameters, including age, sex, disease severity, and BMI classification in patients with psoriasis.
The current study was conducted on psoriasis patients at the Imam Al-Hussein City Hospital in Karbala Province, Iraq, from December 2022 to April 2023. The blood samples of participants were healthy individuals and newly diagnosed, untreated psoriasis patients. Pregnant women, those with chronic conditions, and those receiving psoriasis medication were excluded. A case-control observational study is conducted using convenience sampling to select participants. The PASI scoring method was used to evaluate four body areas, and the sandwich ELISA method is used for immunomarker analysis.
The study finds that psoriasis patients (50 (56%)) were more prevalence than the control (40 (44%)), with no significant difference in age or gender. Females (26 (56%) outnumbered male 14 (35%)) in both groups. There is a significant difference in body mass index (BMI) between healthy control and psoriasis patients, but the average BMI was statistically different. Most patients reported moderate symptoms, with the remainder experiencing severe symptoms. Age differences are not significant, but severe psoriasis patients are older in certain age groups. Immunological markers (IL-17, IL-23 TLR-4, TLR-7,) were found to be higher in psoriasis patients than healthy controls, suggesting a possible involvement in the disease’s origin.
The study explored various aspects of psoriasis, revealing a higher prevalence among patients compared to controls, with no significant differences in age, gender, or BMI. Notably, no significant distinction was found in the severity of psoriasis symptoms between moderate and severe cases. Immunomarkers (IL-17, IL-23, TLR-4, TLR-7) emerged as potential disease indicators, suggesting a crucial role in modulating psoriasis impact on socio-demographic factors. Psoriasis patients exhibited elevated immunological marker levels in severe cases, followed by moderate cases, compared to healthy individuals.