دور العلامات الالتهابية لدى مرضى ارتفاع ضغط الدم في مدينة كربلاء المقدسة

The role of inflammatory markers in hypertensive patients in holy Karbala city

Hypertensive is a common disease that can be dangerous if it is left untreated. Also, many factors can cause high blood pressure, including high fat content, high fats can contribute to hardening of the arteries or thickening of the artery walls; which increases the risk of atherosclerosis, stroke, heart attack, and heart disease. There is a strong relationship between high blood pressure and kidney weakness, this is because uncontrolled hypertensive is a major cause of chronic kidney disease. Chronic kidney disease (CKD) is a major cause of hypertensive, and high urea and creatinine are the most important factors that increase the rate of high blood pressure. Hypertensive significantly increases the risk of cardiovascular disease, kidney failure, and stroke. Hypertensive can be caused by several factors such as excessive salt or alcohol consumption, stress, age, and genetics, family history, obesity, and physical condition.
This study was designed to evaluate the levels of some inflammatory markers which are heat shock protein- 70 (HSP-70), human tumor necrosis factor alpha (TNF-α), high sensitivity C reactive protein (HS CRP), in addition lipid profile, urea and creatinine in hypertension patients. The study included 50 patients suffering from hypertensive and 40 individuals from the healthy control group. Those patients consist of 28 males and 22 females, with ages ranging from 40 to 70 years, they were compared with the healthy group. The parameters were measured in these groups are cholesterol, triglycerides, LDL, HDL, VLDL, urea, creatinine, HSP-70, TNF-α and HS CRP. The result analyzed in significant difference p value ≤ 0.0001 when a comparison was done between the data of patients of high blood pressure and the group of healthy people. It is noticed that the results were higher than the normal limit of cholesterol, triglycerides, LDL, HDL, VLDL, urea and creatinine, Hsp-70, CR-protein in patients with high blood pressure, while the results showed a no significant difference of TNF- α in hypertension patients. In addition, it showed the effect of gender on the levels of parameters by the difference between groups of males and females. That was a significant difference p value = 0.02 in triglycerides, p value = 0.03 with VLDL, p value = 0.01 of LDL and cholesterol No Significant difference with HDL compared to patients of hypertension and patients of hypertension with other diseases, In addition, it was shown that there was no significant difference in TNF-alpha and HS CRP and HSP-70 between patients with high blood pressure only and patients with other diseases, also it was a significant difference p value = 0.05 in the percentage of urea and p value = 0.04 in creatinine in patients hypertension with other diseases when compared with group of patients of hypertension only. The results of effect of age showed that there was no significant difference in the percentage of cholesterol, triglycerides, HDL, LDL, VLDL in the group of age between 40-55 years but in age 56-70 years , Additionally, it showed there was no significant difference P- value ≤ 0.0001 in HSP-70, C-reactive protein, TNF-alpha, creatinine, urea in patients according age. It showed a sensitivity of HSP-70 in hypertension when compared with the control group. Further one, it showed that is a correlation between the groups of BMI were obese, the morbidly obese, and the normal in patients of hypertension with the levels of parameters. The role of duration of disease can be shown by the effect of duration on the levels of parameters.
Immunological cells and inflammation are major contributors to hypertension, which is a risk factor for cardiovascular disease. The results showed a significant difference (P value = ≤ 0.0001) in HSP-70 and HS CRP but there was no significant difference in TNF-alpha in patients of hypertension and results showed a significant difference (P value = ≤ 0.0001) in lipid profile and urea and creatinine.