دور العوامل الموطئه للألتهابات والأجهاد التأكسدي في ظهور حب الشباب

Pro-Inflammatory factors and oxidative Stress In triggering acne

Abstract

Acne vulgaris is a chronic inflammation of pilosebaceous follicles with multi factorial disorder. Four major factors contribute to cause of acne vulgaris: hyperplasia of sebaceous glands and increased sebum secretion, hypercornification of pilosebaceous duct, bacterial infection , particularly by P.acnes(Propionibacterium granulosum), and inflammation. Recent studies on the aetiopathogenesis of acne vulgaris were focused on the role of oxygen free radicals and antioxidant enzymes. when antioxidant enzymes become incapable in oxidative damage, oxygen free radicals initiate lipid peroxidation in cell and organelle membranes. Oxidative stress causes damages to all cellular components through attacks on lipids, proteins and DNA. Among these effects , lipid damage through oxidative stress induced lipid peroxidation is particularly relevant to acne. The chemical pathogenesis of acne was proposed based on oxidative breakdown of lipid in the skin. Lipid peroxides, products of lipid peroxidation, may function as a cause of acne or as an acnegenic agents or both. Supporting data for this lipid peroxidation hypothesis come from a study showing that lipid peroxidation occurs in acne and site specific free radical damage and products of lipid peroxidation might be involved in the initiation of inflammation. Since the etiology and pathogenesis of acne are not completely understood, and a single, primary cause has not been identified, Therefore, this study aimed to investigate the level of particularly pro inflammatory substance which might derive and consequence acne and also examine the Antioxidants activity and their role in the regulation of oxidative stress in acne patients.
This study included acne. collectionThe medical data of 75 samples (50 acne patients and 25 control) from Imam Hussein medical city in a Kerbala –Iraq(during the period from January to march 2021 )were collected.Acne cases were divided into subgroups based on disease severity. Serum biomarkers level were measured for the following parameter: serum SOD, CAT , LOX activity and MDA levels, which were performed using spectrophotometer Technique. The association between biochemical markers and disease severity was evaluated. The efficiency of the predicting value was assessed using receiver operating characteristic (ROC) curve.
Serum LOX and SOD may represent a clinically useful stratification tool that provides important insights in patients with acne. Therefore, the current study could suggest monitoring oxidative stress and antioxidant levels as a good biomarker for prognosis of acne.