تقييم علاقة بعض مؤشرات الايض الحيوية والرصاص مع التغيرات الهرمونية لدى النساء المصابة بمتلازمة المبيض متعدد الكيسات

Rp_Evaluation of the relationship of some vital metabolic indicators and lead with hormonal changes in women with PCOS.pdf

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of childbearing age, which starts from sexual maturity until menopause. It often causes infertility for women with this syndrome in the world. Androgens and multiple ovarian cysts, and they are related to heart and metabolic disorders and their health effects are long-term, and there are studies that indicated that polycystic ovary syndrome has a relationship with obesity and vital metabolic indicators.
Therefore, this study was designed to evaluate the relationship between these indicators and polycystic ovary syndrome in Karbala Governorate, and included 75 samples, including 45 females, were infected with polycystic ovary syndrome, and the diagnosis was made according to Rotterdam criteria 2003 in the Teaching Obstetrics and Gynecology Hospital in Karbala Governorate during February 2022 to May 2022, and 30 healthy females, who have a regular menstrual cycle and have a normal hormone level, and the presence of cysts was not noticed.
Ovarian, and the age was identical in both groups studied and included the age from 18 – 41 years, and the body mass index was calculated (BMI) for all women within the studied groups, and the body mass index (BMI) was greater than 30 kg / m 2 for all women within the study and for both groups.
A questionnaire was filled out for each patient with PCOS and for the control group as well.
The levels of hormones were measured for each group of women with polycystic ovary syndrome and the control group, namely, the luteinizing hormone (LH), the Follicle-stimulating hormone (FSH), Testosterone, Estrogen, and progesterone, as well as the level of some vital indicators such as Gherlin, Leptin ,Adiponectin, Insulin, sugar, Triglycerides, and total Cholesterol for both groups.
The level of Lead (pb) in the blood was also measured for both groups, as one of the possible environmental pollutants affecting PCOS.
The results of the current hormonal study for women with PCOS showed a significant increase (p<0.05) in the level of luteinizing hormone (LH) with a significant probability (0.000), while the follicle-stimulating hormone (FSH) did not show a significant difference between the two groups studied.
We noticed a significant increase (p<0.05) for testosterone, and according to the statistical results, the significant potential was (0.048).
As for the hormones progesterone and estrogen, they did not show significant differences (p>0.05) when compared with the control group. Women with polycystic ovary syndrome did not show a significant effect, while the body mass index did not show a significant effect (p>0.05).
The academic level did not show a significant effect (p>0.05), the living environment also did not show a significant effect, and the social status did not show any significant effect.
As for the indicators of vital metabolism, including insulin, it showed a significant increase (p<0.05) at the level of probability 0.05, and the significant probability was (0.009), but sugar did not show that significant effect, and there was no difference according to the statistical results, and the significant probability of sugar was (0.094).
GHerlin showed a significant decrease (p < 0.05), while Leptin was significantly high when comparing women with PCOS with the control group.
Adiponectin also showed a significant increase when comparing the two groups studied, and the significant probability was (0.000).
Lead did not show a significant difference (p>0.05) when comparing the group of women with PCOS and the control group.
It has been observed that there are correlations between some biomarkers and hormones. There was an inverse correlation between Gherlin and Leptin, as well as Gherlin with the luteinizing hormone LH, and a positive relationship between Gherlin and triglycerides.
We also noticed a positive relationship between leptin and insulin, a positive relationship between adiponectin and testosterone, and an inverse relationship between adiponectin,and insulin.
Also, there was a direct correlation between triglycerides and each of progesterone, insulin and choline.
The results of this study show that obesity (body mass index) is responsible for the rise in leptin, insulin, and testosterone in women with PCOS, and the hormones Gherlin and leptin have a role in the development of PCOS by affecting the hormonal level and some other biomarkers related to this syndrome.