دراسة بعض التغيرات البيوكيميائية في مصل الدم المصاب بحصوات الكلى في مدينة النجف

Rp-A study of Some Biochemical changes in sera patients with kidney stone in Al-Najaf City

The  present  study  was  designed  to  evaluate  biochemical   constituents of the  sera of patients  with renal calculi.  Also, this  research  is  designed  to evaluate  calcium, oxalate  and  total  protein  in  24  hour  urine  for  22  patients compared  with  14  other  healthy  people  as  control  group. The current study deals with the age, sex and smoking effect on the composition of renal calculi and considered to study.

    The  protocol  of  the research  consisted  of  qualitative  analysis  of   renal  calculi. Twenty-eight  calculi  were  obtained  from  (8)  females  and   (20)  males  afflicated  with  Urolithiasis. Their  ages  ranged  from  (7-60)  years.         Biochemical  analysis  of  sera  was  carried out  by  using  quantity  method  analysis and the result was designed to calculate the concentration of  Glucose,urea,Creatinine, uric acid, calcium, phosphorus, total protien,acid  phosphatase  and  alkaline  phosphatase  levels. Showing  of  resulting data demonstrated  that  significant  P<(0.05)  differences  of  serum  glucose  concentration between males and  females.

    The study explained of the effect on biochemical constituent were pointed out that increased significant (p<0.05) postive correlation with age for serum glucose, urea, Creatinine ,uric acid, calcium. while appeared decreased significantly (p>0.05) negative correlation with age for serum phosphorus, Acid phosphatase and Alkaline phosphatase .

   The  peak  age  of  patient  with  renal  calculi  was  found  to  be  in  (7-48)  years. The  effect of smoking factors  not  to have any  changes on the constituents of the study.

Data  of  urinalysis  of  24  hours  were  increased  for  concentration  calcium, oxalate  and  total  protein  of  patient  when  compared  with  healthy  people as control  group.

Qualitative  assay  of  renal  stone  appeared  higher  percentages  uric  acid  , calcium,oxalate,phosphours  and  ammonium   in  calculi  of  males  when  compared  with  that  of  females.

      This study recommendations: Establishment of ideological stone therapy in A L-furat AL-awsat, public educatin,Qualitative analysis of kidney stone ,Using technique (FTIR) ,Control of chronic disease, for example Diabetes mellitus ,Family history ,hypertension, A  history of gout,hyperparathyrodisum and Chronic metabolic acidosis. More studies about relation between smoker and renal calculi .