مستويات المصل ودور تعدد الأشكال الجينية لعامل فون ويلبراند في التسبب في احتشاء عضلة القلب ST-Elevation في المرضى العراقيين وعلاقته بمستويات ADAMTS13

Serum Levels and Role of Von Willebrand Factor Gene Polymorphism in Pathogenesis of ST-Elevation Myocardial Infarction in Iraqi Patients and its Relations with ADAMTS13 Levels

Abstract

Background: ST-elevation myocardial infarction (STEMI) is a clinical syndrome defined by characteristic symptoms of myocardial ischemia in association with persistent electrocardiographic ST elevation (STE) and subsequent release of biomarkers of myocardial necrosis
Aim of the Study:
To see the serial variations in the levels and gene polymorphism of thrombo-inflammatory biomarker von Willebrand factor (VWF) and A Disintegrin and Metalloprotease with Thrombo-Spondin motif (ADAMTS13) over the course of ST- elevation myocardial infarction and to determine their relationship with the another cardiovascular risk markers in Iraqi patients

Materials and Methods: The study design is a case-control study.
A total of 42 samples of ST-elevation myocardial infarction patients are collected from Kerbala Heart Center with age ranged between( 25-75 )years, and other 48 apparently healthy adults also as a control group and determination some biochemical marker creatine kinase and lipid profile was measure by using dirui device. Troponin is measure by cobas e411.
Enzyme-Linked immunosorbent assay (ELISA) was performed using Sandawich method to measure the concentrations of serum VwF and Adamts13

Result: The current study, found that the proportion of men with st elevation MI is greater in men than women. there was a significant difference between blood glucose and lipid profile in st-elevation MI patient and control group. There was statistical significant increase in serum cholesterol, triglycerides and LDL while for VLDL not statistically significant and there was statistical significant increase in serum VWF and reduced level ADAM where in the genetic study The AA, AT and TTgenotypes were significantly raised the risk of ST_Elevation MI

Conclusion: The AA, AT and TTgenotypes were significantly raised the risk of ST_Elevation MI, The results of the current study of genotype distribution of the (rs216311) SNP exhibited a significant associations were noticed between AT, AA, and TT genotype and incidence of ST Elevation patients when compared with those of the control group.
found that the proportion of men with st elevation mi is greater than women. the total number of patients who have blood group A is the largest percentage for O and B in patient with st elevation myocardial infraction. Patients with diabetes mellitus have higher levels of TG and LDL cholesterol. while HDL level was normal, In the current study there was statistical significant increase in serum VWF and reduced level ADAM in St-Elevation MI patient.