University of Kerbala
College of Science / University of Kerbala has discussed the M.A thesis which is entitled ” an Investigation into Hyperd Nano_structures as Drug Delivery System “.
The study, submitted by Maryam Radhi Kadhim, aims at examining self-assembly of organic and inorganic hybrids using polyoxometalate (POM) hexamolybdate, chitosan and dopamine to prepare new three-dimensional nanostructures. These nanostructures are then examined to ensure their suitability as nanocarriers for chemotherapy drug temozolomide (TMZ). The release of temozolomide (TMZ) from nanocarrier has been studied under different pH conditions. The study includes two main components, the first focuses on fabrication of specially designed hierarchical nanostructures to load TMZ drug. The amount of drug loaded on prepared nanostructure of Chitosan-POM and Dopamine-POM was determined using high-performance liquid chromatography (HPLC at different loading times). The second investigates the release process of TMZ drug from nanostructures. The study finds out that preparation of new nanocarriers of chitosan and dopamine with POM loaded with TMZ, and loading percentage was 21% for (Chitosan-POM) and 38% for (Dopamine -POM) via self-assembly as a means of oral drug delivery.
