Investigating the effect of genetic polymorphisms on effectiveness of an oral anticoagulant in patients with atrial fibrillation, College of Pharmacy _ University of Kerbala has discussed the M.A thesis which is entitled “Influence of ABCB1 gene polymorphisms on rivaroxaban Response and Hemorrhagic Events in Patients with Atrial Fibrillation in Iraq”.
The study, which has been presented by Haider Khadir Jaleel, focuses on the relationship between genetic polymorphisms in ABCB1 gene and patients’ response with atrial fibrillation to drug rivaroxaban.
The study examines one of the most common heart disorders as a major factor in strokes and thromboembolisms, shedding light on the impact of genetic variations on determining the drug’s effectiveness and risks.
The thesis shows that certain genotypes are associated with lower plasma drug levels and an increased risk of bleeding, in addition to their potential impact on liver function.
It is concluded that genetic polymorphisms in ABCB1 are a factor influencing safety and effectiveness of treatment, emphasizing the importance of adopting personalized treatment protocols based on genetic testing.