Faculty of Faculty of Applied Medical Sciences / University of Kerbala investigates some immunological and biochemical parameters in female with lupus arthritis.
The thesis, submitted by Muhammad Rabie Naseh, aims at evaluating some biochemical immune parameters in female with lupus arthritis for purpose of identifying them as an indicator of development of the disease.
The thesis concludes that levels of Osteoprotegerin (OPG) and β-crosslaps (β-CTX) increased significantly in lupus arthritis, while levels of Osteocalcin (OC) and Vitamin D3 (Vit-D3) decreased, and levels of OPG and β-CTX are positively related to the activity of disease, while OC and Vit-D3 levels had a negative relationship with disease activity, in addition, β-CTX examination showed excellent diagnostic performance for lupus arthritis and a good indicator of severity of lupus arthritis.
The thesis recommends studying the role of β-CTX in kidney damage. It also recommends integrating β-CTX test with the routine tests performed on lupus erythematosus patients in laboratories of Iraqi Ministry of Health, as well as studying the role of vitamin K and cathepsin K in patients with lupus erythematosus Lupus arthritis.
