تأثير عقار السيفكسيم على الخصوبة و الأجنة في الجرذان البيض

Effect of Cefixime on Embryos and Fertility in White Rats

Abstract :
The first study was carried out on 30 females, distributed to three groups of 10 rats per group, the first group was assigned control group, the second group was injected with 9 (1-10) for pregnancy, while the second group was irrigated with the same concentration of day (11 – 15) for pregnancy, for the purpose of observing the pathological effects in the morphological, physiological and histological parameters of embryos as well as studying the effect of the drug on liver, kidney and maternal ovaries, After observing the effects on the Embryos and ovaries showed deformity in the front end of the treated embryos of the day (1-10) for pregnancy as well as congestion and necrosis in addition to maternal edema. The liver found a blood congestion in the central hepatic vein, while the kidneys were observed in proliferative glomerulonephritis and renal tubules And physiological effects The results of the statistical analysis showed statistically significant differences between the control groups and the two groups of the drug in both the number of implantation, absorption, yellow bodies and dead embryos at the significance level of 0.05
The second experiment included two groups for each group of 10 rats, the first group was a control group, the second group administered the mothers with a concentration of (9 mg) of the drug after birth for 5 consecutive days. The results of the statistical analysis showed that there were statistically significant differences in the weight increase rates depending on the week The results of the statistical analysis showed that there were statistically significant differences in the weight increase between the experimental group and the control group in general in favor of the control group, and the control group exceeded the weight increase rates The results of the statistical analysis showed statistically significant differences in the longitudinal increase rates according to the week either in the individual of the experimental group or in the control group. The results of the statistical analysis showed statistically significant differences in the longitudinal increase rates between the group The experimental group and the control group were generally in favor of the experimental group, and the experimental group excelled at linear increase rates in each week of weeks when compared to the control group
The third experiment consisted of two groups of 10 rats each. The first group was assigned a control group. The second group was injected with 9 mg of the drug for 55 days and the testis and spermus were explained on the 60th day. The test was performed and evaluated. Including sperm concentration, in terms of movement and viability. There was a significant decrease in the preparation of the normal diets of the treated group. The differences were significant at a mean level of 0.05. The researcher also compared the abnormal sperm ratios between the experimental group and the control group. The differences were statistically significant at 0.05. There was also a significant decrease in the total number of patients in the experimental group when compared to control group.

The differences were statistically significant at a mean level of 0.01. It was noticed that there was a significant decrease in the active and inactive sperm of the experimental group when compared to the control group at a mean level of 0.01, while a significant increase was observed for the dead animals of the experimental group when compared to the control group at a statistical significance level of 0.01. However, the study showed statistically significant differences between the treatment group and the control group in terms of the total weight of the testicular and the weight of the right and left testicles at a mean level of 0.05 and during congestion and decrease in sperm numbers.