دراسة إمكانية تحديد بعض الدلائل الحيوية على تسمم الإنسان بسم الاوكراتوكسين A

Rp_Study possibility of some Biomarkers Determind on poisoning of Human by Ochratoxin A pdf

Summary

The results should presence of Ochratoxin A in 90% of blood plasma of nephropathy disease patients, while the blood plasma sample of healthy people was 3% with a significant difference. Its percentage among male patients, as the percentage among females is 48.8%, while the percentage among males is 51.1%.
The results also showed a clear superiority in the concentration rates of Ochratoxin A in the blood plasma of patients relative to a healthy person, as its average concentration in female and male patients was (7.015 and 7.071) ng/ml, respectively, while it was in both healthy females and males ( 0.1, 0.09) ng/mL, respectively.
The results associated with the presence of Ochratoxin A (8-24mg/dl) showed an increase in the level of urea in male patients to 115 mg/dL, while the level in females reached (99.1) mg/dL, while the levels in both healthy females and males were within the(6-21mg/dl) normal level.
The average creatinine level in patients with chronic kidney disease, whether female and male, increased to (4.645, 3.73) ml/dL, respectively, with a significant difference from its levels in a healthy person knowing that the normal level(0.84-1.21mg/dl).
As for albumin levels, it slightly increased in nephropathy than in healthy controls, with an insignificant difference knowing that the normal level(3.5-5.5g/dl)
Also, the level (8–48U/L)of AST enzyme was affected (8-35U/L) in female patients, reaching a ratio of (19.26) international U/L, while its level reached (15.4) international units/liter in healthy patients, with a significant difference at the level of P<0.05.
The results indicated that the levels(4.36U/L) of ALT enzyme were within the normal level(17-55U/L) in patients with nephropathy and in a healthy person.
On the other , the ALP enzyme was affected for female patients, reaching a rate of (125.54) IU/L, while for healthy females it 44.86 IU/L, and for male patients, the percentage was close to what it is in female patients knowing that the normal level(40-129U/L)
The tests for physiological blood parameters showed a decrease in the percentage of HCT in male patients, which amounted to (32.68%) with a significant difference from the percentage of a healthy person knowing that the normal level male (42 – 52) and female (37- 47).
And there was a decrease in the level of hemoglobin in male patients compared to its level in healthy controls, with a small significant difference P<0.05 knowing that the normal level male (14 -18) and female (12 -16).
The results also indicated a decrease in the number of red blood cells in patients compared to healthy controls with a significant difference of P<0.001
The results of physiological blood parameters represented by MCHC, MCH, WBC, and PLT do not showing any significant differences in both males and females from their levels in healthy persons.