تأثير تعدد الشكل الجيني (لجينات UGT1A4 و CYP3A4) على الاستجابة لعقار الاناسترازول في النساء المصابات بمرض سرطان الثدي في العراق

Effect of Genetic Polymorphisms of CYP3A4 and UGT1A4 on Anastrozole Efficacyin Iraqi Breast Cancer Women

Breast cancer is consideredas global problem of health that
affects parenchyma of the breast, with a global incidence of 1.7 million
women diagnosed with breast cancer per year, around the world breast
cancer constituting 25% of all cancers and it is being the second causes of
death in women worldwide following lung cancer. In Iraq,generally and in
Kerbala women specifically, breast cancer is the top of ten among cancer
types, as well as the first cause of death among women.
Aromatase is responsible for final step of estrogen synthesis
which plays an important role in breast cancer pathogenesis, anastrozole as
aromataseenzymeinhibitor drug that is used in therapy of breast cancer
women metabolize mainly through hepatic CYP3A4 and UGT1A4,
polymorphism of anastrozole-metabolizing enzymes have a role in
interindividual variation in anastrozole response and side effect.