تأثير تعدد النمط الجيني ل جين ABCB1 في فعالية عقار الاناستروزول عند النساء العراقيات المصابات بسرطان الثدي

Effect of Genetic Polymorphism of ABCB1 Gene on Anastrozole Efficacy in Iraqi Breast Cancer Women

 Breast cancer is the most frequent cancer among the women
It develops as a result of various interactions between genetic and
environmental factors.
Anastrozole is one of most the common drugs used in treatment of
estrogen receptor (ER) and / or progesterone receptor (PR) positive breast
cancer. Anastrozole is widely used in postmenopausal breast cancer women,
in addition, it is used in premenopausal women with advanced or metastatic
breast cancer. ATP-binding cassette B1 (ABCB1) has been reported to be an
efflux transporter of anastrozole. ABCB1 gene is polymorphic and have
about 40 single nucleotide polymorphisms, which may affect the
pharmacokinetic of drugs and so the clinical outcome. Cytosin 1236
Thymine (C1236T) and Cytosin 3435 Thymine (C3435T) SNPs have been
detected in the present study.