علاقة تعدد الاشكال الجيني لركيزة مستقبلات الانسولين (IRS1) مع الاستجابة العلاجية للمتفورمين لدى النساء المصابات بمتلازمة تكيس المبايض في العراق

Association of Genetic Polymorphism of Insulin Receptor Substrate-1with Therapeutic Response of Metformin in Women with Polycystic Ovary Syndrome in Iraq

Polycystic ovary syndrome (PCOS) is highly prevalent hormonal
disorder among reproductive-aged women. Its clinical manifestations are
heterogeneous, the syndrome diagnosed according to Rotterdam criteria that
depend on hyperandrogenism (clinical and/or biochemical), ovulatory
dysfunction and / or polycystic ovarian morphology. Polycystic ovary
syndrome is associated with hyperinsulinemia and insulin resistance that
affected by insulin receptor substrate 1(IRS1)protein, this proteinis an
important intermediate in insulin signaling and plays a key role in maintaining
the basic function of the cell, so any polymorphism in IRS1 genes acts as a
competitive inhibitor of the insulin receptor. IRS1 polymorphismmay be
associated with susceptibility to insulin resistance, poly cystic ovary
syndrome and variable effect of metformin response in polycystic ovary
syndrome