علاقة تعدد الأشكال الجيني لناقل الكاتيون العضوي الاول مع الاستجابة العلاجية للميتفورمين في النساء المصابات بمتلازمة تكيس المبايض في العراق

Effect of Genetic Polymorphism of Organic Cation Transporter-1 on the Therapeutic Response to Metformin in Women with Polycystic Ovary syndrome in Iraq

Polycystic ovary syndrome (PCOS) is a highly prevalent
endocrine-metabolic disorder that implies severe consequences to female
health, including infertility. Although its exact etiology remains elusive, it is
known to feature several hormonal disturbances, including
hyper and rogenemia, insulin resistance (IR), and hyperinsulinemia. Insulin
appears to disrupt all components of the hypothalamus-hypophysis-ovary
axis and ovarian tissue.
The determinants of the variability in the clinical response to
metformin as insulin sensitizer drug in women with PCOS are multi factorial.
Organic cation transporter 1 (OCT1) plays a crucial role in the hepatic
uptake of metformin. Several OCT1  polymorphism in recent studies showed
a significant effect on metformin response.